{"id":3923,"date":"2025-03-07T12:21:24","date_gmt":"2025-03-07T04:21:24","guid":{"rendered":"https:\/\/imbhg.tcu.edu.tw\/?p=3923"},"modified":"2025-03-07T12:24:00","modified_gmt":"2025-03-07T04:24:00","slug":"%e7%94%b1%e9%95%b7%e6%af%9b%e8%80%81%e9%bc%a0%e8%88%87%e5%9f%ba%e5%9b%a0%e5%b7%a5%e7%a8%8b%e7%9a%84%e7%aa%81%e7%a0%b4-%e8%ab%87%e6%9c%80%e6%96%b0%e5%9f%ba%e5%9b%a0%e8%bd%89%e6%ae%96%e5%8f%8a","status":"publish","type":"post","link":"https:\/\/imbhg.tcu.edu.tw\/?p=3923","title":{"rendered":"\u7531\u9577\u6bdb\u8001\u9f20\u8207\u57fa\u56e0\u5de5\u7a0b\u7684\u7a81\u7834&#8212;-\u8ac7\u6700\u65b0\u57fa\u56e0\u8f49\u6b96\u53ca\u57fa\u56e0\u7de8\u8f2f\u6280\u8853"},"content":{"rendered":"<div class=\"wp-block-image\">\n<figure class=\"alignleft size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"1024\" src=\"https:\/\/imbhg.tcu.edu.tw\/wp-content\/uploads\/2025\/03\/20250307.png\" alt=\"\" class=\"wp-image-3924\" srcset=\"https:\/\/imbhg.tcu.edu.tw\/wp-content\/uploads\/2025\/03\/20250307.png 1024w, https:\/\/imbhg.tcu.edu.tw\/wp-content\/uploads\/2025\/03\/20250307-300x300.png 300w, https:\/\/imbhg.tcu.edu.tw\/wp-content\/uploads\/2025\/03\/20250307-150x150.png 150w, https:\/\/imbhg.tcu.edu.tw\/wp-content\/uploads\/2025\/03\/20250307-768x768.png 768w, https:\/\/imbhg.tcu.edu.tw\/wp-content\/uploads\/2025\/03\/20250307-375x375.png 375w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u64b0\u6587\/\u5716\u7247&nbsp;<span style=\"font-family: Ubuntu;\">\u5f35\u65b0\u4faf\u6559\u6388<\/span><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u00a0\u4eca\u5e74(2025\u5e743\u6708)\u7f8e\u570b\u5fb7\u5dde\u751f\u6280\u516c\u53f8Colossal Biosciences\u5ba3\u4f48\uff0c\u4ed6\u5011\u6210\u529f\u5c07\u9577\u6bdb\u8c61\u7684\u907a\u50b3\u7279\u5fb5\u79fb\u690d\u5230\u666e\u901a\u8001\u9f20\u8eab\u4e0a\uff0c\u57f9\u80b2\u51fa\u64c1\u6709\u6fc3\u5bc6\u9577\u6bdb\u7684\u300c\u9577\u6bdb\u8001\u9f20\u300d\u3002\u9019\u9805\u7a81\u7834\u6027\u7684\u57fa\u56e0\u7de8\u8f2f\u5be6\u9a57\u4e0d\u50c5\u986f\u793a\u51fa\u57fa\u56e0\u8f49\u6b96\u6280\u8853\u7684\u6f5b\u529b\uff0c\u4e5f\u8b93\u300c\u53bb\u6ec5\u7d55\u300d\uff08de-extinction\uff09\u7684\u7814\u7a76\u518d\u5ea6\u6210\u70ba\u5168\u7403\u79d1\u5b78\u754c\u95dc\u6ce8\u7684\u7126\u9ede\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u9577\u6bdb\u8c61\uff08Mammuthus primigenius\uff09\u66fe\u5ee3\u6cdb\u5206\u5e03\u65bc\u6b50\u4e9e\u5927\u9678\u8207\u5317\u7f8e\u6d32\u7684\u9ad8\u7def\u5ea6\u5730\u5340\uff0c\u6700\u5f8c\u7d55\u8de1\u65bc\u7d044000\u5e74\u524d\u3002\u7531\u65bc\u5176\u751f\u6d3b\u74b0\u5883\u6975\u7aef\u5bd2\u51b7\uff0c\u8a31\u591a\u9577\u6bdb\u8c61\u907a\u9ab8\u5f97\u4ee5\u5728\u51b0\u5c64\u4e2d\u4fdd\u5b58\u5b8c\u597d\uff0c\u70ba\u79d1\u5b78\u5bb6\u7814\u7a76\u5176\u57fa\u56e0\u7d44\u63d0\u4f9b\u4e86\u7d55\u4f73\u7684\u689d\u4ef6\u3002Colossal Biosciences\u7684\u7814\u7a76\u5718\u968a\u901a\u904e\u5c0d\u6bd4\u9577\u6bdb\u8c61\u3001\u4e9e\u6d32\u8c61\u8207\u5176\u4ed6\u54fa\u4e73\u52d5\u7269\u7684\u57fa\u56e0\u7d44\uff0c\u7be9\u9078\u51fa\u6578\u500b\u8207\u9577\u6bdb\u8c61\u7279\u5fb5\u76f8\u95dc\u7684\u57fa\u56e0\uff0c\u5982\u5f71\u97ff\u6bdb\u9aee\u751f\u9577\u7684Krt27\u3001\u5f71\u97ff\u8102\u80aa\u4ee3\u8b1d\u7684Fabp2\u4ee5\u53ca\u5f71\u97ff\u6bdb\u8272\u8b8a\u5316\u7684Tgfa\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5728\u672c\u6b21\u5be6\u9a57\u4e2d\uff0c\u7814\u7a76\u4eba\u54e1\u5229\u7528CRISPR\u57fa\u56e0\u7de8\u8f2f\u6280\u8853\uff0c\u5c07\u9019\u4e9b\u7d93\u904e\u7be9\u9078\u7684\u57fa\u56e0\u8b8a\u7570\u5f15\u5165\u666e\u901a\u5be6\u9a57\u9f20\u7684\u57fa\u56e0\u7d44\u5167\u3002\u7d50\u679c\u986f\u793a\uff0c\u9019\u4e9b\u57fa\u56e0\u7684\u6539\u8b8a\u6210\u529f\u8b93\u8001\u9f20\u9577\u51fa\u985e\u4f3c\u9577\u6bdb\u8c61\u7684\u9577\u6bdb\uff0c\u4e14\u6bdb\u8272\u504f\u5411\u9ec3\u8910\u8272\uff0c\u985e\u4f3c\u65bc\u9060\u53e4\u9577\u6bdb\u8c61\u7684\u6bdb\u9aee\u984f\u8272\u3002\u7814\u7a76\u5718\u968a\u5f37\u8abf\uff0c\u9019\u4e9b\u9577\u6bdb\u9f20\u7684\u51fa\u73fe\u4e26\u4e0d\u4ee3\u8868\u9577\u6bdb\u8c61\u80fd\u5920\u88ab\u5b8c\u5168\u5fa9\u6d3b\uff0c\u800c\u662f\u300c\u529f\u80fd\u6027\u53bb\u6ec5\u7d55\u300d\u7684\u4e00\u90e8\u5206\uff0c\u5373\u900f\u904e\u57fa\u56e0\u6539\u9020\u8b93\u73fe\u5b58\u751f\u7269\u627f\u8972\u6ec5\u7d55\u751f\u7269\u7684\u90e8\u5206\u95dc\u9375\u7279\u5fb5\uff0c\u4ee5\u671f\u80fd\u5728\u751f\u614b\u7cfb\u7d71\u4e2d\u767c\u63ee\u985e\u4f3c\u7684\u89d2\u8272\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">CRISPR \u57fa\u56e0\u7de8\u8f2f\u6280\u8853\u662f\u4e00\u7a2e\u7cbe\u78ba\u3001\u9ad8\u6548\u7684\u57fa\u56e0\u6539\u9020\u5de5\u5177\uff0c\u82f1\u6587\u5168\u540d\u70ba Clustered Regularly Interspaced Short Palindromic Repeat\/ CRISPR associated protein 9\uff0c\u6700\u521d\u4f86\u81ea\u7d30\u83cc\u7684\u514d\u75ab\u6a5f\u5236\u3002\u8a72\u6280\u8853\u5229\u7528 CRISPR (\u6210\u7c07\u898f\u5f8b\u9593\u9694\u77ed\u8ff4\u6587\u91cd\u8907) \u5e8f\u5217\u4f86\u8b58\u5225\u7279\u5b9a DNA \u7247\u6bb5\uff0c\u4e26\u7531 Cas9 \u9175\u7d20\u8ca0\u8cac\u5207\u5272 DNA\uff0c\u4f7f\u79d1\u5b78\u5bb6\u80fd\u5920\u522a\u9664\u3001\u63d2\u5165\u6216\u4fee\u6b63\u7279\u5b9a\u57fa\u56e0\u3002CRISPR \u6280\u8853\u5df2\u5ee3\u6cdb\u61c9\u7528\u65bc \u91ab\u5b78\u3001\u751f\u7269\u79d1\u6280\u3001\u8fb2\u696d \u7b49\u9818\u57df\uff0c\u4f8b\u5982\u6cbb\u7642\u907a\u50b3\u75be\u75c5\u3001\u6539\u826f\u4f5c\u7269\u57fa\u56e0\u53ca\u958b\u767c\u6297\u75c5\u83cc\u65b0\u85e5\u3002\u7531\u65bc\u5176\u64cd\u4f5c\u7c21\u55ae\u4e14\u6210\u672c\u4f4e\u5ec9\uff0cCRISPR \u88ab\u8996\u70ba\u57fa\u56e0\u7de8\u8f2f\u9818\u57df\u7684\u4e00\u5927\u9769\u547d\u6027\u7a81\u7834\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u57fa\u56e0\u8f49\u6b96\u8207\u57fa\u56e0\u5243\u9664\u6280\u8853\u524d\u6cbf\uff1a\u6148\u6fdf\u5927\u5b78\u57f9\u80b2\u9802\u5c16\u907a\u50b3\u5b78\u4eba\u624d<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u9577\u6bdb\u8001\u9f20\u7684\u8a95\u751f\u5c55\u793a\u4e86\u57fa\u56e0\u79d1\u6280\u7684\u98db\u901f\u767c\u5c55\uff0c\u800c\u9019\u985e\u5148\u9032\u6280\u8853\u7684\u61c9\u7528\u4e0d\u50c5\u9650\u65bc\u5fa9\u539f\u9060\u53e4\u751f\u7269\u7279\u5fb5\uff0c\u5728\u73fe\u4ee3\u91ab\u5b78\u8207\u751f\u7269\u7814\u7a76\u9818\u57df\u540c\u6a23\u5177\u6709\u6df1\u9060\u5f71\u97ff\u3002\u6148\u6fdf\u5927\u5b78\u5206\u5b50\u751f\u7269\u66a8\u4eba\u985e\u907a\u50b3\u5b78\u7cfb\u9577\u671f\u6295\u5165\u57fa\u56e0\u8f49\u6b96\u8207\u57fa\u56e0\u5243\u9664\u6280\u8853\u7684\u7814\u7a76\uff0c\u81f4\u529b\u65bc\u57f9\u80b2\u5177\u5099\u524d\u77bb\u6027\u8996\u91ce\u8207\u5be6\u4f5c\u80fd\u529b\u7684\u907a\u50b3\u5b78\u4eba\u624d\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u672c\u7cfb\u8ab2\u7a0b\u6db5\u84cb \u57fa\u56e0\u8f49\u6b96\u6280\u8853\u3001CRISPR \u57fa\u56e0\u7de8\u8f2f\u6280\u8853\u3001\u6a21\u5f0f\u751f\u7269\u61c9\u7528 \u53ca \u907a\u50b3\u5b78 \u7b49\u6838\u5fc3\u9818\u57df\uff0c\u70ba\u5b78\u751f\u63d0\u4f9b\u6700\u65b0\u7684\u5c08\u696d\u77e5\u8b58\uff0c\u4e26\u5f37\u8abf\u5176\u5728\u5be6\u969b\u7814\u7a76\u4e2d\u7684\u61c9\u7528\u3002\u4f8b\u5982\uff0c\u672c\u7cfb \u5f35\u65b0\u4faf \u8207 \u5b6b\u5fb7\u73ca \u6559\u6388\u900f\u904e ATF3 \u57fa\u56e0\u5243\u9664\u5c0f\u9f20 \u9032\u884c\u7814\u7a76\uff0c\u767c\u73fe\u8a72\u57fa\u56e0\u5243\u9664\u5f8c\uff0c\u5c0f\u9f20\u5728\u58d3\u529b\u4e0b\u7684\u8178\u80c3\u9053\u640d\u50b7\u66f4\u52a0\u56b4\u91cd\uff0c\u9032\u4e00\u6b65\u8b49\u5be6 ATF3 \u57fa\u56e0\u6216\u5176\u4fc3\u9032\u5291\u53ef\u80fd\u5177\u6709\u8178\u80c3\u4fdd\u8b77\u4f5c\u7528 (DOI: 10.3390\/ijms25105261)\u3002 \u9019\u985e\u7814\u7a76\u4e0d\u50c5\u52a0\u6df1\u5c0d\u75be\u75c5\u6a5f\u5236\u7684\u7406\u89e3\uff0c\u4ea6\u70ba\u7cbe\u6e96\u91ab\u7642\u63d0\u4f9b\u6f5b\u5728\u7684\u6cbb\u7642\u7b56\u7565\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u96a8\u8457\u57fa\u56e0\u79d1\u6280\u7684\u6301\u7e8c\u7a81\u7834\uff0c\u6148\u6fdf\u5927\u5b78\u5206\u5b50\u751f\u7269\u66a8\u4eba\u985e\u907a\u50b3\u5b78\u7cfb\u7684\u7562\u696d\u751f\u6191\u85c9\u7d2e\u5be6\u7684\u57fa\u790e\u8a13\u7df4\u8207\u524d\u6cbf\u6280\u8853\u7684\u638c\u63e1\uff0c\u5728\u751f\u6280\u7522\u696d\u3001\u91ab\u7642\u7814\u7a76\u8207\u5b78\u8853\u754c\u7686\u5c55\u73fe\u51fa\u5353\u8d8a\u7684\u7af6\u722d\u529b\u3002\u672a\u4f86\uff0c\u8a72\u7cfb\u5c07\u6301\u7e8c\u8207\u570b\u969b\u63a5\u8ecc\uff0c\u63a8\u52d5\u57fa\u56e0\u79d1\u6280\u7684\u5275\u65b0\u767c\u5c55\uff0c\u57f9\u990a\u66f4\u591a\u80fd\u5920\u5f15\u9818\u6642\u4ee3\u7684\u907a\u50b3\u5b78\u5c08\u696d\u4eba\u624d\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u6df1\u5165\u4e86\u89e3<\/strong><strong>&nbsp;<\/strong>\u6148\u6fdf\u5927\u5b78\u5206\u5b50\u751f\u7269\u66a8\u4eba\u985e\u907a\u50b3\u5b78\u7cfb<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/imbhg.tcu.edu.tw\">https:\/\/imbhg.tcu.edu.tw<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/collego.edu.tw\/Highschool\/DepartmentIntro?dept_id=108010\">https:\/\/collego.edu.tw\/Highschool\/DepartmentIntro?dept_id=108010<\/a><\/p>\n\n\n\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe loading=\"lazy\" title=\"\u6148\u5927\u5206\u907a\u7cfb\u4ecb\u7d39\" width=\"900\" height=\"506\" src=\"https:\/\/www.youtube.com\/embed\/-HiDw487Eek?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe>\n<\/div><\/figure>\n\n\n\n<figure class=\"wp-block-embed is-type-wp-embed\"><div class=\"wp-block-embed__wrapper\">\n<blockquote class=\"wp-embedded-content\" data-secret=\"D7c1XA3GAB\"><a href=\"https:\/\/imbhg.tcu.edu.tw\/?p=3469\">\u5c31\u696d\u65b0\u4eae\u9ede:\u764c\u75c7\u6b21\u4e16\u4ee3\u57fa\u56e0\u5b9a\u5e8f\uff08Next-Generation Sequencing\uff0c\u7c21\u7a31 NGS\uff09\u6aa2\u6e2c\u9810\u8a082024\u5e74\u7d0d\u5165\u5065\u4fdd\u7d66\u4ed8<\/a><\/blockquote><iframe loading=\"lazy\" class=\"wp-embedded-content\" sandbox=\"allow-scripts\" security=\"restricted\" style=\"position: absolute; visibility: hidden;\" title=\"\u5c31\u696d\u65b0\u4eae\u9ede:\u764c\u75c7\u6b21\u4e16\u4ee3\u57fa\u56e0\u5b9a\u5e8f\uff08Next-Generation Sequencing\uff0c\u7c21\u7a31 NGS\uff09\u6aa2\u6e2c\u9810\u8a082024\u5e74\u7d0d\u5165\u5065\u4fdd\u7d66\u4ed8 &#8212; \u5206\u5b50\u751f\u7269\u66a8\u4eba\u985e\u907a\u50b3\u5b78\u7cfb\" src=\"https:\/\/imbhg.tcu.edu.tw\/?p=3469&#038;embed=true#?secret=Je63AhDzI1#?secret=D7c1XA3GAB\" data-secret=\"D7c1XA3GAB\" width=\"600\" height=\"338\" frameborder=\"0\" marginwidth=\"0\" marginheight=\"0\" scrolling=\"no\"><\/iframe>\n<\/div><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/ioh.tw\/talks\/%E6%85%88%E6%BF%9F%E5%88%86%E9%81%BA%E7%B3%BB-%E6%88%B4%E5%AD%9F%E7%BE%A4-tw-study-tcu-bde\">https:\/\/ioh.tw\/talks\/%E6%85%88%E6%BF%9F%E5%88%86%E9%81%BA%E7%B3%BB-%E6%88%B4%E5%AD%9F%E7%BE%A4-tw-study-tcu-bde<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u76f8\u95dc\u8cc7\u8a0a\u53ca\u5831\u5c0e<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe loading=\"lazy\" title=\"\u7d93\u79fb\u690d\u7d55\u7a2e\u9577\u6bdb\u8c61\u57fa\u56e0 \u8001\u9f20\u9577\u51fa\u53e4\u751f\u7269\u9577\u6bdb\uff5c20250305 \u516c\u8996\u665a\u9593\u65b0\u805e\" width=\"900\" height=\"506\" src=\"https:\/\/www.youtube.com\/embed\/Sa3Qk6FybAY?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe>\n<\/div><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2025.03.03.641227v1\">https:\/\/www.biorxiv.org\/content\/10.1101\/2025.03.03.641227v1<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.nature.com\/articles\/d41586-025-00684-1\">https:\/\/www.nature.com\/articles\/d41586-025-00684-1<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a 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